Cobimetinib (Cotellic) is a kinase inhibitor that plays an important role in the field of cancer treatment.

Indications of Cobimetinib (Cotellic)

Melanoma Treatment

Cobimetinib, in combination with vemurafenib, is specifically indicated for the treatment of adult patients with unresectable or metastatic melanoma confirmed to have BRAF V600E or V600K mutations via testing.

Before initiating the combination treatment regimen of cobimetinib and vemurafenib, the presence of BRAF V600E or V600K mutations must be confirmed through tumor sample testing.

Histiocytic Neoplasm Treatment

As a monotherapy regimen, cobimetinib is indicated for the treatment of adult patients with histiocytic neoplasms.

This indication covers a variety of histiocytic diseases, providing a new treatment option for the relevant patient population.

Dosage Specifications and Properties of Cobimetinib (Cotellic)

Drug Dosage Form and Appearance

Cobimetinib is available as 20 mg tablets. These tablets are white, round, film-coated, with the inscription "COB" on one side.

The core components of the tablet include microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, and magnesium stearate.

The film coating layer consists of polyvinyl alcohol, titanium dioxide, polyethylene glycol 3350, and talc.

Chemical Properties

Cobimetinib fumarate is the active pharmaceutical ingredient of cobimetinib.

Its chemical name is (S)-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate.

This compound exists in the form of fumarate, appearing as a white to off-white solid, and exhibits pH-dependent solubility characteristics.

Storage Methods for Cobimetinib (Cotellic)

Storage Temperature Conditions

Cobimetinib must be stored at room temperature below 30°C (86°F).

Packaging Specification Description

The medication is supplied in bottle packaging, with each bottle containing 63 tablets of 20 mg.

The packaging adopts a standard pharmaceutical safety bottle design to ensure the integrity and safety of the medication during storage.

Stability Assurance Measures

During storage, the medication must always be kept in its original container. This measure is crucial for preventing the medication from being affected by the external environment and thus reducing its efficacy.