Cobimetinib(Cotellic)
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Reference price:
Manufacturer:
Roche
Formulation:
TABLET
Validity period:
24 months
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.

Cotellic(Cobimetinib) Instructions:Uses,Dosage, Side Effects

Cotellic (cobimetinib) is an oral kinase inhibitor primarily utilized in oncology. It works by inhibiting MEK1 and MEK2, key enzymes in the MAPK/ERK signaling pathway, which plays a crucial role in cell division and survival. By blocking this pathway, Cotellic helps slow down the growth of cancer cells.

This drug is approved for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. Additionally, it is approved for the treatment of adult patients with histiocytic neoplasms as a monotherapy. It is essential for clinicians to confirm the presence of the BRAF V600E or V600K mutation before initiating Cotellic in melanoma patients.

Generic name

Cobimetinib(Cotellic)
English name
Cobimetinib
Alternative Names
Cotellic
Drug prices
Indications

1.Unresectable or Metastatic Melanoma:

For adults with BRAF V600E/K mutation-positive disease, in combination with vemurafenib.

2.Histiocytic Neoplasms:

As monotherapy for adults with histiocytic neoplasms (e.g., Erdheim-Chester disease, Langerhans cell histiocytosis).

Therapeutic Target
Reversible inhibitor of MEK1/2 (mitogen-activated protein kinase kinase 1/2), blocking the RAS/RAF/MEK/ERK pathway.
Active Ingredients
Cobimetinib fumarate.
Dosage form
TABLET
specifications
20mg * 63 tablets
Description

Physical Properties: White to off-white, round tablets debossed with “COB” on one side.

Inactive Ingredients:

Core: Microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate.

Coating: Polyvinyl alcohol, titanium dioxide, polyethylene glycol 3350, talc.

Dosage and Administration

1.Melanoma:

60 mg once daily for 21 days followed by 7 days off (28-day cycle).

Confirm BRAF V600 mutation before initiation.

2.Histiocytic Neoplasms:

60 mg once daily for 21 days followed by 7 days off (28-day cycle).

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