Metyrapone is a medication specifically used for diagnosing adrenal cortex insufficiency, and its purchase and use are subject to strict requirements for medical professionalism.

How to Purchase Metyrapone?

Overseas Purchase

Patients may choose to consult and purchase metyrapone at hospital pharmacies or formal drugstores in countries or regions where the medication has been launched.

Since drug prices may be affected by factors such as regional differences and exchange rate fluctuations, patients need to make budgets and plans in advance before purchasing.

Purchase Through Medical Service Institutions

Patients can consult domestic overseas medical service institutions that cooperate with international pharmacies or pharmaceutical companies.

These institutions can usually provide legal import channels and offer professional consultation and guidance.

Precautions for Purchase and Use of Metyrapone

Strict Contraindications

Patients with adrenal cortex insufficiency.

Patients allergic to metyrapone or any of its excipients.

Important Pre-Medication Assessment

Discontinue medications that affect pituitary or adrenal cortex function, and allow for a period of at least 5 half-lives to avoid interfering with test results.

Evaluate the patient's adrenal response ability to exogenous ACTH (adrenocorticotropic hormone).

Abnormal thyroid function may affect the test response.

Use in Special Populations

Risk in pregnant women: Metyrapone can cross the placenta and may reduce fetal cortisol production. When this test is used in the second and third trimesters of pregnancy, the fetal pituitary gland is found to respond to enzyme blockade.

Precautions for lactating women: Metyrapone and its active metabolite, metyrapol, are present in human milk. The benefits of breastfeeding need to be weighed against the potential effects of the medication.

Patients with hepatic impairment: Patients with cirrhosis may have an impaired response to metyrapone.

Methods to Distinguish Authenticity of Metyrapone

Verification of Packaging Markings

Dosage form: 250mg soft capsules.

Color: White to off-white.

Shape: Oblong and opaque.

Marking: One side is printed with red "HRA".

Verification of Manufacturer Information

Metyrapone is manufactured by Catalent Germany Eberbach GmbH and owned by HRA Pharma Rare Diseases.

When purchasing, confirm that the manufacturer information on the drug packaging is consistent with this.

Check of Drug Approval Number

Querying the drug approval number through official channels is an effective method to verify the authenticity of the drug.

Formal drugs all have a unique approval number, which can be verified on the website of the relevant drug regulatory authority.