Tirzepatide is a novel dual receptor agonist classified as a long-acting GIP/GLP-1 receptor agonist. As a significant breakthrough in the treatment of type 2 diabetes mellitus, its unique dual mechanism of action and remarkable glucose-lowering and weight-reducing effects have garnered considerable clinical attention.

What is Tirzepatide?

Pharmacological Actions

Tirzepatide exerts a synergistic glucose-lowering effect by simultaneously activating the GIP receptor and GLP-1 receptor.

Its molecular structure consists of 39 amino acids, and it binds to endogenous albumin via a C20 fatty acid side chain, significantly extending its half-life and enabling once-weekly administration.

The medication promotes insulin secretion in a glucose concentration-dependent manner, inhibits glucagon secretion, and improves insulin sensitivity.

Indication Scope

This product is indicated for blood glucose control in patients with type 2 diabetes mellitus, but only when the effects of adequate dietary therapy and exercise therapy remain unsatisfactory.

It is important to note that this medication is not a substitute for insulin, and the patient’s insulin-dependent status must be strictly evaluated before use.

Specifications and Properties of Tirzepatide

Specification Description

All strengths (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg) are supplied as 0.5 mL of solution per prefilled pen, with each box containing two injection pens.

Property Description

Formulation Type: Combined product consisting of a prefilled syringe with a fixed injection needle and an injector.

Appearance: Colorless to slightly yellowish to slightly brownish clear liquid, or liquid with a slight milky luster.

pH Value: 6.5–7.5.

Osmolality Ratio: Approximately 1 (relative to physiological saline).

Composition

Active Ingredient: Tirzepatide (content corresponding to each strength).

Excipients: Disodium hydrogen phosphate heptahydrate 0.7 mg, sodium chloride 4.1 mg.

pH Adjusters: Hydrochloric acid (as needed), sodium hydroxide (as needed).

Storage Conditions of Tirzepatide

Storage Environment Requirements

Routine Storage: Store at 2–8℃ in the dark.

Room Temperature Storage: May be stored at room temperature below 30℃, but the outer packaging must be retained, and the product must be used within 21 days.

Shelf Life: 24 months.

Prohibition: Avoid freezing; do not use if frozen crystals form.