ExtraSuperTadarise is a combination preparation mainly used for the treatment of erectile dysfunction (ED) and premature ejaculation (PE) in men.
Indications of ExtraSuperTadarise
Core Indications
Erectile Dysfunction (ED): Suitable for adult men who have persistent or recurrent inability to achieve or maintain a sufficient erection to complete satisfactory sexual intercourse.
Premature Ejaculation (PE): Used for the treatment of primary or secondary premature ejaculation, which can significantly prolong the intravaginal ejaculatory latency time (IELT).
Pharmacological Actions
Tadalafil: Selectively inhibits the PDE5 enzyme, increases the concentration of cGMP in the corpus cavernosum, and promotes smooth muscle relaxation and blood perfusion.
Dapoxetine: As a short-acting SSRI (selective serotonin reuptake inhibitor), it enhances ejaculatory control by inhibiting the reuptake of 5-HT (serotonin).
Dosage Form, Strength and Characteristics of ExtraSuperTadarise
Dosage Form and Composition
Dosage Form: Film-coated tablets for oral administration.
Strength: The common dosage contains 20 mg of Tadalafil and 60 mg of Dapoxetine per tablet; some versions may offer other dosage combinations.
Appearance: Oval or round tablets, with colors varying by manufacturer (commonly yellow or orange), and may have score lines or markings on the surface.
Excipients: Usually include inactive ingredients such as microcrystalline cellulose, lactose, and croscarmellose sodium.
Chemical Properties
Tadalafil: Molecular formula is C₂₂H₁₉N₃O₄, molecular weight is 389.41; it is almost insoluble in water and slightly soluble in ethanol.
Dapoxetine: Molecular formula is C₂₁H₂₃NO, molecular weight is 305.4; it is easily soluble in organic solvents.
Usage and Dosage of ExtraSuperTadarise
Recommended Administration Regimen
Dosage: Usually 1 tablet (20 mg Tadalafil / 60 mg Dapoxetine) per time, taken orally 1-3 hours before sexual activity. The maximum administration frequency is once every 24 hours.
Adjustment Principles
Hepatic Impairment: Dose reduction is required for patients with mild or moderate hepatic impairment; it is contraindicated in patients with severe hepatic impairment.
Renal Impairment: When creatinine clearance is < 30 mL/min, it is recommended to halve the dose.
Drug Interactions: Avoid concurrent use with nitrates and potent CYP3A4 inhibitors (e.g., ketoconazole).
Administration Precautions
Fasting or Postprandial: It can be taken with food, but a high-fat meal may delay the time to reach peak concentration.
Need for Sexual Stimulation: Sexual stimulation is required to trigger the drug effect.
Contraindicated in patients allergic to any of its components.
Use with caution in patients with severe cardiovascular diseases.
Concurrent use with nitrate drugs is strictly prohibited (may cause life-threatening hypotension).
