Binimetinib is a targeted therapy for metastatic or unresectable melanoma with BRAF V600E or V600K mutations, and has achieved remarkable efficacy in clinical applications. Like other drugs, Binimetinib may also cause a range of adverse reactions during use. So, what are the adverse effects of Binimetinib(Mektovi)?

What are the adverse reactions of Binimetinib(Mektovi)?

The adverse effects of Binimetinib involve multiple systems, including the digestive system, cardiovascular system, eye, etc. Understanding these adverse reactions can help patients detect and deal with them in a timely manner during use.

digestive system

The digestive system is one of the main sites where Binimetinib triggers adverse reactions. The most common adverse effects include nausea, diarrhea, vomiting, and abdominal pain. These symptoms usually appear early in treatment and may gradually lessen as treatment continues. For people with severe symptoms, your doctor may recommend adjusting the dose or temporarily stopping the medication.

Cardiovascular system

Binimetinib may also cause adverse effects of the cardiovascular system, such as cardiomyopathy and venous thromboembolism. Cardiomyopathy may present with decreased left ventricular myocardial ejection fraction and, in severe cases, may lead to congestive heart failure. Venous thromboembolism can lead to serious consequences such as deep vein thrombosis or pulmonary embolism. When using Binimetinib, patients should have regular ECG and echocardiography, as well as coagulation monitoring.

Dosage of Binimetinib(Mektovi)?

Knowing the correct dosage of Binimetinib can ensure the therapeutic effect and reduce adverse reactions.

Recommended dose

The recommended dose of Binimetinib is 45 mg twice a day, about 12 hours apart. The medicine can be taken with or without food.

Frequency of medications

Within 6 hours of taking the next dose of Binimetinib, if the dose is missed, there is no need to make up the dose. For the therapeutic effect, patients should take their medications on time and avoid missing doses or overdosing.

Dose adjustments

In the course of using Binimetinib, if there are adverse reactions, the doctor may adjust the dose on a case-by-case basis. For serious adverse reactions such as cardiomyopathy and venous thromboembolism, your doctor may recommend suspending the medication, reducing the dose, or stopping it permanently. For people with moderate to severe liver impairment, doctors may also adjust the dose.

During the dose adjustment process of Binimetinib, patients should pay close attention to their physical condition and report any discomfort to their doctor in a timely manner. Patients should also have regular check-ups to assess the response to treatment and adverse effects.