Perfluorohexyl Octane Eye Drops (Miebo) is a new dry eye treatment drug approved in the United States in 2023, with its active ingredient being 100% perfluorohexyl octane.

What Are the Side Effects of Perfluorohexyl Octane Eye Drops (Miebo)?

Common Side Effects

Blurred vision is the most common ocular adverse reaction, with an incidence rate of less than 4%.

Approximately 1-3% of patients experience conjunctival hyperemia.

These reactions are mostly transient and usually do not affect the continuation of treatment.

Watch for Severe Side Effects of Perfluorohexyl Octane Eye Drops (Miebo)

Hypersensitivity Reactions

Perfluorohexyl Octane Eye Drops are contraindicated in patients allergic to perfluorohexyl octane.

Some patients may experience allergic reactions, such as eyelid swelling, rash, or difficulty breathing.

If relevant symptoms occur after medication use, the drug must be discontinued immediately and medical attention sought.

Risks in Special Populations

Pregnant Women: Animal studies have shown that when rabbits were exposed to a dose 41 times the recommended human dose, miscarriages, decreased fetal weight, and maternal toxicity occurred. Data in humans is not yet clear, and the drug should be used only after weighing the pros and cons.

Lactating Women: It is unknown whether perfluorohexyl octane is excreted in breast milk. It is recommended to consult a doctor before making a decision on use.

Children and Elderly People: The safety of the drug in people under 18 years of age has not been established. There are no significant differences in safety or efficacy between elderly patients and younger populations.

Precautions for Using Perfluorohexyl Octane Eye Drops (Miebo)

Specifications for Contact Lens Use

Contact lenses must be removed before using the eye drops, and you should wait for at least 30 minutes after instillation before reinserting them.

The drug ingredients may be absorbed by the contact lenses, which could cause irritation or reduce the therapeutic effect.

Correct Eye Drop Instillation Steps

Unscrew the bottle cap, keep the bottle upright, and gently squeeze the bottle body.

While squeezing, invert the bottle opening and release the pressure to draw in air.

Keep the bottle in an inverted position, align the bottle opening with the eye, and squeeze again to instill the liquid.

If both eyes require treatment, repeat the above steps.

Storage and Expiration Date

Store the drug in an environment at 15℃–25℃. After opening the bottle, it can be used until the expiration date marked on the bottle.

If the liquid changes color or becomes turbid, it must be discontinued immediately.

Drug Interaction Information

No clear drug interactions have been identified so far. However, if other eye drops need to be used at the same time, the interval between uses should be no less than 5 minutes to avoid diluting or flushing out the drug.