Riociguat Tablets (Adempas) is a soluble guanylate cyclase stimulant, mainly used for the treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.

How to Purchase Riociguat Tablets (Adempas)

Overseas Purchase

Patients can choose to consult and purchase the medication at hospital pharmacies or regular drugstores in countries or regions where Riociguat Tablets (Adempas) have been launched.

Since drug prices may be affected by factors such as regional differences and exchange rate fluctuations, patients need to make a budget and plan well before purchasing.

Purchase through Medical Service Institutions

Patients can consult domestic overseas medical service institutions that cooperate with international pharmacies or pharmaceutical companies.

These institutions can usually provide legal import channels and offer professional consultation and guidance.

Precautions for Purchase and Use of Riociguat Tablets (Adempas)

Absolute Contraindicated Populations

Pregnant women.

Patients who are concurrently using nitrates or nitric oxide donors.

Patients using phosphodiesterase inhibitors.

Patients who are concomitantly using other soluble guanylate cyclase stimulants.

Patients with pulmonary arterial hypertension associated with idiopathic interstitial pneumonia.

Special Risk Warnings

Embryotoxicity Risk: The drug poses a teratogenic risk to the fetus. Pregnancy must be ruled out before medication, and effective contraceptive measures must be continuously adopted during the treatment period.

Hypotension Risk: The drug can lower blood pressure, so special caution is required for patients with hypovolemia, severe left ventricular outflow tract obstruction, etc.

Bleeding Risk: Clinical trials show that the incidence of severe bleeding in patients taking Riociguat Tablets is 2.4%.

Medication in Special Populations

Renal Insufficiency: Not recommended for patients with a creatinine clearance rate < 15 mL/min or those receiving dialysis.

Hepatic Insufficiency: Not recommended for patients with severe hepatic insufficiency.

Smoking Patients: Dosage adjustment may be required; the plasma concentration in smokers is 50%-60% lower than that in non-smokers.

How to Identify the Authenticity of Purchased Riociguat Tablets (Adempas)

Identification by Appearance Characteristics

0.5 mg: White film-coated tablets, engraved with the "BAYER" cross logo on one side, and "0.5" and "R" on the other side.

1 mg: Light yellow film-coated tablets, engraved with the "BAYER" cross logo on one side, and "1" and "R" on the other side.

1.5 mg: Yellow-orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "1.5" and "R" on the other side.

2 mg: Light orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "2" and "R" on the other side.

2.5 mg: Red-orange film-coated tablets, engraved with the "BAYER" cross logo on one side, and "2.5" and "R" on the other side.

Inspection of Packaging Markings

Clear batch number and expiration date.

Complete package insert.

Anti-counterfeiting marks and REMS (Risk Evaluation and Mitigation Strategy) program certification information.