Tacrolimus Capsules (Astagraf XL) are calcineurin inhibitor-type immunosuppressants, primarily used to prevent rejection reactions after organ transplantation. By inhibiting the activation of T lymphocytes and the release of cytokines, the drug exerts its core immunosuppressive effect, and it serves as an important foundational medication for anti-rejection therapy following transplantation.

Indications for Tacrolimus Capsules (Astagraf XL)

Primary Indications

In combination with other immunosuppressants, Tacrolimus Capsules are indicated for adult patients and pediatric patients capable of swallowing capsules completely as prophylactic treatment for organ rejection after kidney transplantation.

It is particularly important to note that this drug is not approved for use in liver transplant patients; in particular, it may increase the risk of death in female liver transplant patients. Clinical use must strictly comply with the instructions.

Specifications and Properties of Tacrolimus Capsules (Astagraf XL)

Dosage Form and Specifications

0.5 mg capsules: Light yellow cap and orange body. The body is printed with the red marking "647", and the cap is labeled "0.5 mg".

1 mg capsules: White cap and orange body. The body is printed with the red marking "677", and the cap is labeled "1 mg".

5 mg capsules: Gray-red cap and orange body. The body is printed with the red marking "687", and the cap is labeled "5 mg".

The capsules are packaged in hard gelatin shells. Their active ingredient is tacrolimus, and the excipients include ethyl cellulose, hypromellose, magnesium stearate, and lactose monohydrate.

The capsule shell contains gelatin, titanium dioxide, iron oxide, and sodium lauryl sulfate.

The composition ratios of capsules with different specifications remain consistent.

Storage Requirements for Tacrolimus Capsules (Astagraf XL)

Storage Temperature

The drug should be stored at room temperature of 25°C (77°F), with short-term fluctuations between 15°C and 30°C permitted.

Protection from Light and Moisture

It should be kept in the original packaging bottle, away from direct sunlight or humid environments.

Safe Disposal

Expired or no longer needed drugs should be properly discarded to prevent access by children.