Lemborexant (Dayvigo) is a novel orexin receptor antagonist that improves insomnia symptoms by regulating the wakefulness signaling pathway.

How Effective is Lemborexant (Dayvigo) in Treatment?

Improvement in Sleep Onset

Lemborexant can significantly shorten the time it takes for patients to fall asleep, helping them enter a sleep state more quickly. The effect remains stable during long-term treatment, and no significant reduction in tolerance has been observed.

Effect on Sleep Maintenance

Lemborexant can reduce the number of nighttime awakenings, prolong total sleep time, and improve sleep efficiency.

Indicated Populations and Contraindications for Lemborexant (Dayvigo)

Target Patient Populations

Adult patients with insomnia: Particularly suitable for those with both difficulty falling asleep and sleep disruptions.

Patients with mild or moderate hepatic impairment: Dosage adjustment is required (e.g., the maximum dose for patients with moderate hepatic impairment is 5mg per day).

Elderly patients: May use the drug, but the risk of falls needs to be carefully evaluated, and it is recommended to start with a low dose.

Populations Requiring Caution

Patients with severe hepatic impairment: Use is not recommended.

Patients with a history of depression or suicidal tendencies: Close monitoring of emotional changes is required.

Patients with impaired respiratory function: Such as those with moderate to severe obstructive sleep apnea or chronic obstructive pulmonary disease (COPD).

Medication Monitoring for Lemborexant (Dayvigo)

Pre-Medication Assessment

Comprehensive medical history collection: Rule out insomnia caused by other underlying causes (such as anxiety, hyperthyroidism, etc.).

Screening for drug interactions: Avoid concurrent use with strong CYP3A inhibitors/inducers (e.g., itraconazole, rifampicin).

Observation of Adverse Reactions

Monitor for daytime drowsiness and complex sleep behaviors (e.g., unconscious activities).

Be alert to worsening mood or suicidal ideation (especially in patients with depression).

Dosage adjustment for special populations: Elderly patients or those with hepatic impairment need regular rechecks of liver function.

Key Points for Patient Education

Correct medication administration: Take immediately before bedtime and ensure 7 hours of bed rest after taking the drug.

Avoid alcohol: Alcohol may enhance the central nervous system depressant effect.

Driving and operating machinery: On the next day, confirm that alertness has been restored before engaging in high-risk activities.