Trabectedin (brand name: YONDELIS; Chinese alias: Tabiteding), with the English name trabectedin, is a highly effective anti-tumor drug. It is indicated for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma in patients who have previously received anthracycline-based therapy. Its storage and administration methods are directly related to the drug's efficacy. So, what are the storage methods for trabectedin (YONDELIS)?
Storage Methods for Trabectedin (YONDELIS)
Trabectedin (YONDELIS) is an injectable preparation, so special attention must be paid to its storage. When storing trabectedin, the following points should be noted:
Storage Conditions and Environmental Requirements
As an injectable drug, trabectedin has relatively strict storage conditions. According to the drug instruction manual, trabectedin should be stored in a refrigerator at a temperature of 2°C to 8°C. This temperature range can maximize the slowing down of the drug's degradation rate and extend its shelf life.
Storage Containers and Packaging
Trabectedin is usually stored in sterile vials. These vials are designed to maintain the sterility of the drug and prevent external contamination. During storage, the original packaging should be kept intact; do not open or damage the packaging arbitrarily, so as to reduce the risk of the drug being exposed to air.
Medication Precautions for Trabectedin (YONDELIS)
The dosage of trabectedin (YONDELIS) needs to be adjusted based on the patient's body weight, liver function, and the occurrence of adverse reactions.
Preparation and Inspection Before Medication
Before administering trabectedin, medical staff need to carry out a series of preparation and inspection work. This includes confirming the drug's specification, dosage, and expiration date, as well as checking whether the drug has abnormal conditions such as discoloration, precipitation, or particles. It is also necessary to confirm that the infusion set and filter used meet the requirements in the drug instruction manual, so as to reduce the risks during drug preparation and infusion.
Dosage Adjustment and Monitoring During Medication
During the medication period, medical staff should closely monitor the patient's vital signs and laboratory indicators, such as neutrophil count, creatine phosphokinase level, and liver function. Once abnormalities or adverse reactions occur, measures should be taken immediately, such as suspending drug administration, reducing the dosage, or discontinuing the drug permanently.
By following strict storage conditions, conducting thorough preparation and inspection before medication, and implementing dosage adjustment and monitoring during medication, we can maximize the therapeutic effect of trabectedin while minimizing the patient's risks and adverse reactions.
