The use of imetelstat requires close cooperation between physicians and patients. Every step—from pre-treatment preparation and monitoring during infusion to daily self-management—is critical to treatment safety and efficacy.
I. Pre‑treatment Preparation and Evaluation
1. Provide Complete Medical History and Current Medications
(1) Before treatment, you should proactively inform your physician of all past medical conditions, especially bleeding tendencies, liver and kidney function status, and history of infections.
(2) At the same time, list all medications you are currently using, including prescription drugs, over‑the‑counter products, vitamins, and herbal remedies, to avoid potential drug interactions.
2. Undergo Necessary Baseline Tests
(1) Laboratory tests such as complete blood count and liver/kidney function must be completed before starting treatment to establish your personal baseline health data.
(2) Women of childbearing age also need a pregnancy test; treatment can begin only after a negative result is confirmed.
3. Understand the Pre‑medication Regimen
(1) Approximately 30 minutes before each infusion, you will receive antihistamines and corticosteroids as pre‑medication to reduce the risk of infusion‑related reactions.
(2) Patients should cooperate with healthcare staff to complete this step; it must not be omitted.
II. Monitoring and Cooperation During Infusion
1. Full Cooperation with Monitoring During Infusion
(1) The drug is given as a slow intravenous infusion over about 2 hours.
(2) If you experience headache, flushing, chest tightness, joint or muscle pain, or any other discomfort during the infusion, notify the nurse immediately so that the infusion rate can be adjusted or the administration paused.
(3) It is recommended to remain in the hospital for at least 1 hour of observation after the infusion ends.
2. Complete Regular Blood Count Monitoring on Schedule
(1) In the early treatment phase, a complete blood count should be checked weekly; thereafter, testing is required before each dose.
(2) This is the key basis for assessing platelet and neutrophil levels and for deciding whether to continue or adjust treatment. Be sure to cooperate and complete these tests on time.
3. Strictly Adhere to the Dosing Interval
(1) This product is administered once every 4 weeks. It is advisable to record each treatment date to avoid missed or delayed doses.
(2) If you need to adjust the schedule for any reason, you must discuss it with your physician; do not change it on your own.
III. Daily Self‑management
1. Watch for Signs of Bleeding and Infection
(1) In daily life, pay attention to any new petechiae or ecchymoses on the skin, as well as abnormal gum bleeding, nosebleeds, or other unusual bleeding.
(2) Monitor your body temperature daily and note any sore throat, cough, or pain during urination, which could indicate infection.
If any abnormality is found, contact your medical team promptly.
2. Take Bleeding Precautions
(1) Use a soft‑bristled toothbrush and an electric razor, and avoid sharp instruments.
(2) Keep walkways clear at home to prevent tripping or bumping.
(3) If you experience black stools, blood in the urine, or vomiting blood, seek immediate medical attention.
3. Comply with Contraception and Breastfeeding Requirements
(1) Women of childbearing age must use effective contraception during treatment and for one week after the last dose.
(2) If pregnancy is suspected during treatment, inform your physician immediately.
(3) Breastfeeding is not recommended during treatment and for one week after discontinuation.
Note: This article is a scientific reference on medication precautions. The specific treatment regimen and any adjustments must follow the individualized guidance of your attending physician and should not be used as a basis for self‑medication.
