Glutathione Tablets (Tathion) are commonly used clinically as a detoxifying and hepatoprotective medication. Correct administration, dosage, and understanding of precautions are essential to ensure efficacy and safety.

I. Dosage and Administration of Glutathione Tablets

1. Standard Dosage Regimen

(1) Calculated as reduced glutathione, the usual adult dose is 50–100 mg orally, 1–3 times daily.

(2) The specific dosage should be adjusted appropriately according to the patient’s age and severity of symptoms.

(3) This drug is available in 50 mg and 100 mg tablets, as well as 20% powder for flexible clinical use.

2. Dosage Adjustment in Special Populations

(1) Dosage for pediatric patients must be adjusted based on age and body weight.

(2) Elderly patients may use the standard dosage, but attention should be paid to the effects of physiological decline in hepatic and renal function.

(3) When used for hyperemesis gravidarum or pregnancy-induced hypertension syndrome in pregnant women, it should be taken strictly at the recommended dose under medical supervision; do not increase or decrease the dosage without medical advice.

3. Administration Method

(1) Tablets should be removed from the PTP blister pack before use; do not swallow with the packaging.

(2) The powder is 20% concentration, meaning each 1 g contains 200 mg of glutathione. Accurate weighing is required for administration.

(3) The powder must be stored in a sealed container after opening to prevent moisture absorption.

(4) Take orally with an adequate amount of warm water to facilitate disintegration and absorption.

4. Recommended Duration of Treatment

(1) The treatment course should be determined by the specific indication and severity of the condition.

(2) For acute poisoning, discontinuation may be considered under medical supervision after symptom relief.

(3) For chronic diseases or pregnancy-related symptoms, complete the full course as prescribed.

(4) If symptoms do not improve significantly, seek timely follow-up to evaluate whether the regimen needs adjustment.

II. Precautions for Glutathione Tablets

1. Contraindicated Populations

(1) Contraindicated in patients hypersensitive to glutathione or any excipients.

(2) Patients with a history of allergy should inform their doctor before use.

2. Adverse Reactions Monitoring

(1) Glutathione is generally well-tolerated, but a small number of patients may experience side effects.

(2) Adverse reactions with an incidence <0.1% include:

Allergic reactions: rash, etc.

Gastrointestinal symptoms: anorexia, nausea, vomiting, stomach pain, etc.

(3) If any discomfort occurs during treatment, consult a doctor promptly. Discontinue use and seek medical attention immediately in case of allergic reaction.

3. Special Packaging Precautions

(1) Glutathione Tablets are packaged in PTP (aluminum-plastic blister) packs and must be removed before administration.

(2) Do not swallow the PTP blister together with the tablet; otherwise, the rigid sharp edges may injure the esophageal mucosa, potentially leading to severe complications such as perforation and mediastinitis.

4. Drug Interactions

(1) Data on drug interactions are limited. Based on its mechanism, co-administration with drugs requiring hepatic metabolism and detoxification may enhance liver detoxification capacity.

(2) If you are taking other medications, including prescription drugs, over-the-counter drugs, and health supplements, inform your doctor before use for evaluation of potential regimen adjustments.

5. Precautions for Lactation

(1) Glutathione should be used with caution in breastfeeding women.

(2) A decision should be made to continue or discontinue breastfeeding after balancing the therapeutic benefit and the benefits of breastfeeding.

(3) It is unknown whether glutathione is excreted in human milk. If breastfeeding is continued during treatment, closely monitor the infant for any abnormal reactions.

(4) If possible, allow an appropriate interval between drug administration and breastfeeding.

6. Disposal of Expired Medicines

(1) The shelf life is 3 years for tablets and 5 years for powder.

(2) Expired medicines must not be taken or discarded randomly.

(3) The powder should be stored in a tightly closed container after opening. Discontinue use if caking, discoloration, or abnormal odor is observed, indicating possible deterioration.